| Kidney Function Discovery Sheds Light On Genetic Complexity Of Disease |
| To find a cure for cancer, haemophilia and other diseases, researchers need to be looking for complex, interacting genetic factors, according to the authors of a new study. A new study, published in the Journal of Clinical Investigation by researchers at the Centenary Institute, Royal Prince Alfred Hospital (RPA) and The Australian National University (ANU), has exposed a greater level of genetic complexity for diseases than was originally thought.
11/28/2008
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| International Medical Team Announces Patient Results In Adult Stem Cell Clinical Study For Pulmonary Hypertension |
| Dr. Leonel Fernandez Liriano, Professor of Medicine at Pontifical Catholic University School of Medicine (PCUSM), announced nine month follow up results for the first patient treated with engineered stem cells in a clinical study of primary pulmonary hypertension. The stem cells are extracted from patients' own blood and trained to become new blood vessels. Zannos Grekos, M.D.
11/27/2008
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| Why Does It Take So Long For A Correct Diagnosis Of Pulmonary Hypertension? |
| Lack of awareness of pulmonary hypertension is one of the reasons why it takes on average up to two years for a correct diagnosis of this rare lung disease. This year's week-long campaign included a series of national fundraising and press events, organised by the national charity, Pulmonary Hypertension Association UK (www.phassociation.uk.com), and will culminate in the patient annual conference on 14 November.
11/26/2008
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| Study Shows No Benefit From Drug Widely Used To Prevent Premature Births |
| When a pregnant woman goes into early labor, her obstetrician may give her drugs to quiet the woman's uterus and prevent premature birth. New research shows, however, that one popular drug works no better than a placebo at maintaining pregnancy after the initial bout of preterm labor is halted, say scientists at the Stanford University School of Medicine, Lucile Packard Children's Hospital and Santa Clara Valley Medical Center.
11/26/2008
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| Higher Risk Of Adult Diabetes May Be Explained By Potassium Loss From Blood Pressure Drugs |
| Johns Hopkins researchers have discovered that a drop in blood potassium levels caused by diuretics commonly prescribed for high blood pressure could be the reason why people on those drugs are at risk for developing type 2 diabetes. The drugs helpfully accelerate loss of fluids, but also deplete important chemicals, including potassium, so that those who take them are generally advised to eat bananas and other potassium-rich foods to counteract the effect.
11/25/2008
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| Third Pivotal Phase 3 Study For NicOx' Naproxcinod Shows Positive Efficacy, Safety And Blood Pressure Results |
| NicOx S.A. (NYSE Euronext Paris: COX) announced that the third pivotal phase 3 study for naproxcinod in patients with OA of the hip showed a highly statistically significant result (p
11/25/2008
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| Rasilez HCT(R) Receives Recommendation For European Approval As A Single-pill Combination To Treat High Blood Pressure |
| Rasilez HCT® (aliskiren and hydrochlorothiazide) received a positive opinion from the European Committee for Medicinal Products for Human Use (CHMP) recommending marketing authorization as a new treatment for high blood pressure. Rasilez HCT is a single-pill combination of two high blood pressure medicines - first-in-class direct renin inhibitor Rasilez®[1] (aliskiren) and the diuretic hydrochlorothiazide (HCT).
11/23/2008
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| Physicians Should Closely Monitor Elderly Patients With Kidney Damage And Look For Signs Of Organ Failure |
| Acute kidney injury (AKI) - which is often caused by trauma, illness, or surgery - predisposes elderly individuals to the most serious form of chronic kidney disease (CKD), known as end stage renal disease (ESRD), according to a study appearing in the January 2009 issue of the Journal of the American Society Nephrology (JASN). The findings indicate that close medical follow-up is important for maintaining the health of patients who have experienced kidney damage.
11/20/2008
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| Sunshine Deficit May Diminish Vitamin D Levels And Harm Cardiovascular Health |
| The temperature might not be the only thing plummeting this winter. Many people also will experience a decrease in their vitamin D levels, which can play a role in heart disease, according to a new review article in Circulation. Vitamin D deficiency results in part from reduced exposure to sunlight, which is common during cold weather months when days are shorter and more time is spent indoors.
11/18/2008
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| Hypertension Develops Early, Silently, In African-American Men |
| Young and healthy African-American men have higher central blood pressure and their blood vessels are stiffer compared to their white counterparts, signs that the African American men are developing hypertension early and with little outward sign, according to a new study.
11/18/2008
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| FREEDOM-C Trial Of Oral Treprostinil In Pulmonary Arterial Hypertension Fails To Meet Primary Endpoint |
| United Therapeutics Corporation (Nasdaq: UTHR) announced the results of the FREEDOM-C trial of oral treprostinil, a sustained-release formulation of treprostinil, in pulmonary arterial hypertension (PAH). Preliminary analysis demonstrates that the trial did not achieve statistical significance for the primary endpoint, six minute walk (6MW) distance at Week 16.
11/18/2008
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| Breaking Study Supports Noninvasive Central Blood Pressure As A Treatment Target |
| AtCor Medical (ASX: ACG), the developer and marketer of the SphygmoCor(R) system, which measures central blood pressures and arterial stiffness noninvasively, today announced that a new study* funded by the National Institutes of Health (NIH) found that when patients' central pulse pressures exceeded 50 mm of mercury, there was a significant increase in cardiovascular events.
11/17/2008
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| Rasilez®, First-in-class Direct Renin Inhibitor, Provides Greater Reduction In High Blood Pressure Than ACE Inhibitor Ramipril |
| New clinical data presented show first-in-class direct renin inhibitor Rasilez® (aliskiren), known as Tekturna® in the US, provides significantly greater blood pressure reductions in patients with high blood pressure aged 65 and over, compared to the angiotensin-converting enzyme (ACE) inhibitor ramipril[1].
11/15/2008
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| High Blood Pressure: Over 50 Percent Of People With The Condition Are Unaware They Are Hypertensive |
| More than half of people diagnosed with high blood pressure do not have it under control and many more go undiagnosed, according to research carried out at the University of Warwick. Professor Franco Cappuccio from Warwick Medical School at the University of Warwick led the only UK team to participate in a European study examining awareness, treatment and control of high blood pressure, or hypertension.
11/13/2008
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| Is Sildenafil Safe In Cirrhosis Patients? |
| Sildenafil is valuable in the treatment of erectile dysfunction and pulmonary hypertension in patients with end-stage liver disease through inhibition of the type-5 phosphodiesterase. The type-5 phosphodiesterase is also present in human mesenteric arteries. The effect of sildenafil on splanchnic blood flow and portal hypertension remains essentially unknown.
11/13/2008
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