ALA ALPHA LIPOIC ACID
Alpha Lipoic Acid
ALA is regarded as THE top antioxidant. It is unique
in that it is both fat and water-soluble, controls "hydroxyl
radicals," regenerates and helps prevent deficiencies
in other antioxidants [like vitamin C and vitamin E]
and increases glutathione, your body's chief natural
detoxifier and a powerful ally against cancer.
Researchers believe that antioxidants such as vitamins
C and E and the carotenoids, as well as alpha lipoic
acid, work most effectively in a synergistic manner-in
combination with each other, as a team. ALA is sometimes
referred to as a network antioxidant. This is because
Lipoic acid is the only antioxidant with the ability
to regenerate and recycle itself along with other antioxidants
such as vitamins C & E.
The structure of ALA is very small which allows it
to easily slip through cell membranes. Many other antioxidants
are too large to pass through the cell membrane. ALA
is one of the very few substances that can actually
cross the blood/brain barrier to enter the brain and
go directly where it is needed most.
ALA plays an essential role in cellular and muscular
energy production. ALA is a coenzyme in the metabolic
process, specifically it is necessary for the conversion
of glucose to energy Alpha Lipoic Acid speeds the removal
of glucose (sugar) from the blood and breaking down
sugar for the production of ATP, cell fuel. This is
of particular interest to those with diabetes. ALA is
crucial for energy production.
ALA supplementation causes increased levels of glutathione,
which helps the body dispose of toxins. Glutathione
protects the brain from free radical damage, and low
levels of glutathione in the brain have been associated
with brain disorders such as stroke, Parkinson’s,
Alzheimer’s disease and dementia.
Benefits of ALA depend upon which type of ALA is administered.
- Recent studies suggest that ALA bolsters the antioxidant
defenses in HIV-positive people.
- UC Berkeley researchers found that ALA inhibited
the growth of a protein linked with the growth of
Types of ALA
There are two forms of alpha lipoic acid.
R-ALA - is the form found naturally
occurring within the body and is the biologically active
form of alpha lipoic acid.
S-ALA - is the unnatural, synthetic
byproduct created during the production of alpha lipoic
acid. By itself S-ALA is not very effective.
Separating out S-ALA from R-ALA is expensive, so most
manufacturers don’t bother. Generally when you
purchase ALA, you will be given a 50/50 mixture of S-ALA
& R-ALA. So check bottle specifically states 100%
R-ALA, you are only getting a 50/50 blend.
Differences Between R-ALA and S-ALA
Many studies have proven that R-ALA is up to 12 times
as effective as S-ALA. This is due to the many unique
benefits R-ALA offers and the problems with S-ALA
Benefits of R-Lipoic Acid
R-Lipoic acid is the only form of lipoic acid that
your body synthesizes and can safely metabolize. It
is also the only form of lipoic acid that is proven
- significantly increase or maintain levels of other
antioxidants including Coenzyme Q10, vitamin C, vitamin
E and glutathione.
- protect body fats against oxidative damage, chelate
harmful metals and reverse stress damage in your heart.
- reduce disease causing oxidative stress with aging
by significantly increasing cellular and mitochondrial
antioxidant activity, thereby preventing mitochondrial
- significantly reduce inflammation, an underlying
cause of aging.
- protect the brain from neuro-degeneration associated
with aging, improve memory, reduce brain damage and
reverse cognitive dysfunction
- reduce the gain in body fat from aging by significantly
increasing insulin sensitivity, enhancing glucose
transport, and increasing metabolic rate.
- extend total life span
Problems of S-lipoic acid
S-Lipoic acid produces limited beneficial effects since
it cannot bind with key enzymes. S-Lipoic acid also
produces different biological actions than R-Lipoic
acid, some of which may be undesirable.
- At high concentrations, S-Lipoic acid inhibits mitochondria
metabolism and the antioxidant activity of R-lipoic
- S-Lipoic acid is metabolized in the outer cell membrane.
This may interfere with R-Lipoic acid’s ability
to penetrate the inner mitochondrial membrane and
Best food sources: spinach, broccoli, and red meat.
Supplementation can be used for both preventative and
General Supplement: with 120 mg a
Preventive dosage: 100 - 200mg daily
Therapeutic doses: up to 600 - 800mg/day
to reverse symptoms from neuropathy, to assist diabetics
with other complications such as cataracts or macular
degeneration, or to assist the body in fighting off
- Side effects even at higher dosages are practically
nonexistent except possibly allergic skin reaction.
- Blood glucose monitoring is advised.
Life Glow Plus, and Super Life Glow, each, contain
5 mg per daily dose of Alpha.
Other major antioxidants of the body.
Vitamin C, Vitamin E, Beta-carotene (Pro-vitaminA),
Glutathione (Cysteine, glutamic acid and glycine), Methionine,
Cysteine, Coenzyme q-10, (Co-Q-10), Selenium, Zinc,
Melatonin, DHEA, Phytochemicals (Flavonoids and polyphenolics)